Journal
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
Volume 20, Issue 2, Pages 126-137Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2008.11.002
Keywords
ADAMs; Cell adhesion; Signalling; Inflammation; Cancer
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Funding
- Deutsche Forschungsgemeinschaft Sonderforschungsbereich [415, 617]
- Belgian Federal Science Policy Office and the Center of Excellence [IAP VIP6/43]
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There is an exciting increase of evidence that members of the disintegrin and metalloprotease ( ADAM) family critically regulate cell adhesion, migration, development and signalling. ADAMs are involved in ectodomain shedding of various cell surface proteins such as growth factors, receptors and their ligands, cytokines, and cell adhesion molecules. The regulation of these proteases is complex and still poorly understood. Studies in ADAM knockout mice revealed their partially redundant roles in angiogenesis, neurogenesis, tissue development and cancer. ADAMs usually trigger the first step in regulated intramembrane proteolysis leading to activation of intracellular signalling pathways and the release of functional soluble ectodomains. (C) 2008 Elsevier Ltd. All rights reserved.
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