Journal
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
Volume 20, Issue 7, Pages 849-855Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2009.06.004
Keywords
Nuclear organisation; Genomic interactions; Epigenetic regulation; Review
Categories
Funding
- European Union FP6 (Epigenome Network of Excellence and STREP 3D Genome)
- Agence Nationale de la Recherche
- Ministere de l'Enseignement Superieur (ACI BCMS)
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The chromosome conformation capture (3C) technique and its genome-wide applications ('4C') have identified a plethora of distal DNA sequences that are frequently in close spatial proximity. In many cases, these have been correlated with transcriptional regulation of the interacting genes, but the functional significance of many of the extreme long-range and interchromosomal interactions remains unclear. This review summarises our current understanding of how chromatin conformation can impinge on gene expression, the major questions that need to be addressed to understand this more fully, and how these questions may be answered in the near future. (C) 2009 Elsevier Ltd. All rights reserved.
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