Journal
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
Volume 20, Issue 3, Pages 365-374Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2008.12.012
Keywords
Mitochondria; Fusion; Division; Large GTPase; Cell homeostasis
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Funding
- National Institute of General Medical Science [RO1 GM083131]
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM083131] Funding Source: NIH RePORTER
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Discovery of various molecular components regulating dynamics and organization of the mitochondria in cells, together with novel insights into the role of mitochondrial fusion and division in the maintenance of cellular homeostasis, have provided some of the most exciting breakthroughs in the last decade of mitochondrial research. The focus of this review is on the regulation of mitochondrial fusion and division machineries. The newly identified factors associated with mitofusin/OPA1-dependent mitochondrial fusion, and Drp1-dependent mitochondrial division are discussed. Furthermore, the most recent findings on the role of mitochondrial fusion and division in the maintenance of cell function are also reviewed here in some detail. (C) 2009 Elsevier Ltd. All rights reserved.
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