Journal
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
Volume 20, Issue 5, Pages 607-619Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2009.05.002
Keywords
Nuclear transport; Gametogenesis; Spermatogenesis; Review; Reproduction
Categories
Funding
- NHMRC of Australia [384108, 545916, 331005, 384105]
- Australian Research Council [348239, DP0878102]
- Monash University
- National Health and Medical Research Council of Australia [545916] Funding Source: NHMRC
- Australian Research Council [DP0878102] Funding Source: Australian Research Council
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Adult fertility requires appropriate and coordinated instruction of somatic and germ cell activity during lineage specification, development and maturation. Driven by alterations in the complement of nuclear proteins such as transcription factors and chromatin remodelling components, these events proceed by sequential changes in gene expression in response to a myriad of signalling cues. Controlled access of proteins to the nucleus is a key driver of developmental switches. This review discusses key examples of regulated nucleocytoplasmic transport during mammalian gametogenesis and the mechanisms underpinning these transport events, focusing on examples critical for the establishment of fertility. (C) 2009 Elsevier Ltd. All rights reserved.
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