Journal
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
Volume 20, Issue 7, Pages 877-884Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2009.07.009
Keywords
Morphogenesis; Cytoskeleton; Adhesion; Planar cell polarity; Fluctuations
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Funding
- Wellcome Trust
- Fundacao para a Ciencia e Tecnologia
- BBSRC
- BBSRC [BB/F012845/1] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/F012845/1] Funding Source: researchfish
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Morphogenesis is the process whereby cells assemble into tissues and organs. Recent studies of this process have revealed heterogeneity of individual cell behaviours that contrasts with the deterministic activity of tissues as a whole. Here we review these observations and suggest that fluctuations and heterogeneities are a central substrate for morphogenesis and that there might exist mechanisms dedicated to the averaging of these fluctuations to ensure robust and reproducible behaviours at the tissue level. (C) 2009 Published by Elsevier Ltd.
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