Journal
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
Volume 20, Issue 2, Pages 201-210Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2008.11.014
Keywords
Presenilin; Regulated intramembrane proteolysis; beta-Catenin; Calcium; Apoptosis
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Funding
- National Institutes of Health [AG025973, F32GM083604]
- Washington University Alzheimer's Disease Research Center [P50AG05681]
- Japan Society for the Promotion of Science
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Over the years the presenilins (PSENs), a family of multi-transmembrane domain proteins, have been ascribed a number of diverse potential functions. Recent in vivo evidence has supported the existence of PSEN functions beyond its well-established role in regulated intramembrane proteolysis. In this review, we will briefly discuss the ability of PSEN to modulate cellular signaling pathways through gamma-secretase cleavage of transmembrane proteins. Additionally, we will critically examine the proposed roles of PSEN in the regulation of beta-catenin function, protein trafficking, calcium regulation, and apoptosis. (C) 2008 Elsevier Ltd. All rights reserved.
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