Journal
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
Volume 19, Issue 1, Pages 34-41Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2007.07.003
Keywords
matrix metalloproteinase; inflammation; cytokine; chemokine
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Funding
- NHLBI NIH HHS [K08 HL068780, HL068780, K08 HL084385, R01 HL093022, K08 HL084385-02, K08 HL068780-06, HL084385] Funding Source: Medline
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An increased expression of members of the matrix metalloproteinase (MMP) family of enzymes is seen in almost every human tissue in which inflammation is present. Through the use of models of human disease in mice with targeted deletions of individual MMPs, it has become clear that MMPs act broadly in inflammation to regulate barrier function, inflammatory cytokine and chemokine activity, and the generation of chemokine gradients. Individual MMPs regulate both normal and pathological inflammatory processes, and therefore, developing rational therapies requires further identification of specific MMP substrates and characterization of the downstream consequences of MMP proteolytic activity. (C) 2007 Elsevier Ltd. All rights reserved.
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