Journal
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
Volume 19, Issue 3, Pages 234-244Publisher
ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2008.01.002
Keywords
PIX; GIT; Arf; Cdc42; Rac
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Funding
- NCI NIH HHS [R0-1 CA092354, R01 CA092354, R01 CA092354-01A2] Funding Source: Medline
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Arf and Rho GTP-binding proteins coordinately regulate membrane dynamics and cytoskeletal rearrangements. The Cdc42/Rac guanine nucleotide exchange factor PIX and the Arf GTPase-activating protein GIT form a stable complex in cells. The PIX-GIT complex functions to integrate signaling among Arf, Cdc42, and Rac proteins in response to cues emanating from integrins, heterotrimeric G proteins, receptor tyrosine kinases, and cell-cell interactions. A concept that emerges from the literature is that the PIX-GIT complex serves as a cassette to elicit changes in cell shape essential for polarized cell responses in a wide range of biological contexts. (C) 2008 Elsevier Ltd. All rights reserved.
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