Journal
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
Volume 19, Issue 3, Pages 271-282Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2008.01.004
Keywords
review; oogenesis; migration; epithelial-mesenchymal transition; apical-basal polarity
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Funding
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM060501] Funding Source: NIH RePORTER
- NIGMS NIH HHS [R01 GM060501-08, R01 GM060501, GM60501] Funding Source: Medline
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Epithelial morphogenesis is important for organogenesis and pivotal for carcinogenesis, but mechanisms that control it are poorly understood. The Drosophila follicular epithelium is a genetically tractable model to understand these mechanisms in vivo. This epithelium of follicle cells encases germline cells to create an egg. In this review, we summarize progress toward understanding mechanisms that maintain the epithelium or permit migrations essential for oogenesis. Cell-cell communication is important, but the same signals are used repeatedly to control distinct events. Understanding intrinsic mechanisms that alter responses to developmental signals will be important to understand regulation of cell shape and organization. (C) 2008 Elsevier Ltd. All rights reserved.
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