Journal
SEMINARS IN CANCER BIOLOGY
Volume 22, Issue 5-6, Pages 411-416Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcancer.2012.04.008
Keywords
Neural crest; EMT; Development
Categories
Funding
- National Institutes of Health [R03DE022521, HD037105]
- California Institute of Technology
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The epithelial-to-mesenchymal transition (EMT) is an important event converting compact and ordered epithelial cells into migratory mesenchymal cells. Given the molecular and cellular similarities between pathological and developmental EMTs, studying this event during neural crest development offers and excellent in vivo model for understanding the mechanisms underlying this process. Here, we review new and old insight into neural crest EMT in search of commonalities with cancer progression that might aid in the design of specific therapeutic prevention. (C) 2012 Elsevier Ltd. All rights reserved.
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