Journal
SEMINARS IN CANCER BIOLOGY
Volume 20, Issue 5, Pages 281-293Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcancer.2010.10.009
Keywords
DNA polymerase; Proofreading; Mismatch repair; Mutator; Cancer
Categories
Funding
- National Institutes of Health [R01 ES09927, R01 CA098243, R01 CA111582, P20 CA103728, P01 AG01751, P01 CA77852]
- National Institute of Environmental Health Sciences [P30 ES07033]
- Seattle Children's Hospital
- Regional Medical Center
- Burroughs Wellcome Fund
- NATIONAL CANCER INSTITUTE [R01CA098243, R01CA111582, P20CA103728, P01CA077852] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES [P30ES007033, R01ES009927] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON AGING [P01AG001751] Funding Source: NIH RePORTER
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Cancer is fueled by mutations and driven by adaptive selection. Normal cells avoid deleterious mutations by replicating their genomes with extraordinary accuracy. Here we review the pathways governing DNA replication fidelity and discuss evidence implicating replication errors (point mutation instability or PIN) in carcinogenesis. (C) 2010 Elsevier Ltd. All rights reserved.
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