Journal
SEMINARS IN CANCER BIOLOGY
Volume 19, Issue 2, Pages 97-102Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcancer.2008.10.003
Keywords
Chemokines; Chemokine receptors; Tumour invasion; Neuroblastoma
Categories
Funding
- Associazione Italiana per la Ricerca Sul Cancro, Italy
Ask authors/readers for more resources
Chemokines and their receptors have emerged as pivotal regulators of turnout growth, progression, and metastasis. Here we review the current knowledge on chemokines and receptors likely involved in the development of metastasis of neuroectodermal tumours, with emphasis on neuroblastoma. In this respect, we discuss the controversial role of the CXCR4/CXCL12 axis in bone marrow localization of neuroblastoma cells. In addition, we focus on the ability of neuroblastoma-derived chemokines such as CCL2 and CX3CL1 to attract lymphoid cells to the tumour site. Finally, chemokine receptor and function in other neuroectodermal tumours of adulthood (i.e. melanoma and small cell lung cancer) are discussed. (C) 2008 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available