Journal
SEMINARS IN CANCER BIOLOGY
Volume 18, Issue 1, Pages 45-52Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcancer.2007.08.002
Keywords
focal adhesion kinase; tension; mechanotransduction; cell migration
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Funding
- NCI NIH HHS [R01 CA080606-05, CA 29243, R01 CA029243, CA 80606, R37 CA029243-19, P01 CA040042-21, P01 CA040042, R37 CA029243] Funding Source: Medline
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Growing evidence indicates that critical steps in cancer progression such as cell adhesion, migration, and cell cycle progression are regulated by the composition and organization of the microenvironment. The adhesion of cancer cells to components of the microenvironment and the forces transmitted to the cells via the actinomyosin network and the signaling complexes organized within focal adhesions allow cancer cells to sense the local topography of the extracellular matrix and respond efficiently to proximal growth and migration promoting cues. Focal adhesion kinase (FAK) is a nonreceptor tyrosine kinase that is over expressed in a variety of cancers and plays an important role in cell adhesion, migration, and anchorage-dependent growth. In this review, we summarize evidence which implicate FAK in the ability of cells to sense and respond to local forces from the microenviromment through the regulation of adhesion dynamics and actinomyosin contractility, and we discuss the potential roles of FAK as a mechanosensor in the progression of cancer. (C) 2007 Elsevier Ltd. All rights reserved.
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