Journal
SEMINARS IN CANCER BIOLOGY
Volume 18, Issue 6, Pages 423-436Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcancer.2008.09.003
Keywords
Immune evasion; KSHV; Gammaherpesviruses
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A hallmark of herpesviruses is a lifelong persistent infection, which often leads to diseases upon immune suppression of infected host. Kaposi's sarcoma-associated herpesvirus (KSHV), also known as human is etiologically linked to the development of Kaposi's sarcoma (KS), primary effusion herpesvirus 8 (HHV8), lymphoma (PEL), and Multicentric Castleman's disease (MCD). In order to establish a persistent infection, KSHV dedicates a large portion of its genomic information to sabotage almost every aspect of host immune system. Thus, understanding the interplay between KSHV and the host immune system is important in not only unraveling the complexities of viral persistence and pathogenesis, but also discovering novel therapeutic targets. This review summarizes current knowledge of host immune evasion strategies of KSHV and their contributions to KSHV-associated diseases. (C) 2008 Published by Elsevier Ltd.
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