Journal
SEMINARS IN CANCER BIOLOGY
Volume 18, Issue 2, Pages 103-110Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcancer.2008.01.008
Keywords
RNA interference; microRNA; tumor suppressor; oncogene
Categories
Funding
- NCI NIH HHS [5R21CA116060, 5K01CA098176] Funding Source: Medline
- NATIONAL CANCER INSTITUTE [K01CA098176, R21CA116060] Funding Source: NIH RePORTER
Ask authors/readers for more resources
Cancer progression is mediated by overexpression of oncogenes and downregulation or loss of tumor suppressors. Proteins, which were traditionally categorized into these groups, have been recently joined by a species of RNA molecules known as microRNAs (miRNAs). miRNAs belong to a class of approximately 22-nt-long non-coding RNAs found in eukaryotes that hinder gene expression by inducing degradation or inhibiting translation of select mRNAs. A growing number of miRNAs have been implicated in promoting or suppressing tumorigenesis in a variety of tissues. The supporting evidence ranges from suggestive expression profiling data to direct functional validation using methods of forward and reverse genetics. We discuss the nature of published results, as well as the merits and pitfalls of various approaches aimed at identification of cancer-related miRNAs and their mRNA targets. (C) 2008 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available