Journal
SEIZURE-EUROPEAN JOURNAL OF EPILEPSY
Volume 22, Issue 10, Pages 893-896Publisher
W B SAUNDERS CO LTD
DOI: 10.1016/j.seizure.2013.06.014
Keywords
Transcranial magnetic stimulation; Refractory status epilepticus; Intensive care unit; Epilepsia partialis continua
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Funding
- Epilepsy Foundation Clinical Research Training Fellowship
- ABF/AES/EF Susan Spencer Clinical Research Training Fellowship
- NIH-NINDS T32 Institutional Research Training Grant in Cognitive Neurology
- Harvard Catalyst
- Center for Integration of Medicine and Technology (CIMIT)
- Harvard-Thorndike Clinical Research Center at Beth Israel Deaconess Medical Center
- Harvard Clinical and Translational Science Center from the National Center for Research Resources, National Institutes of Health [M01-RR-01066, UL1 RR025758]
- National Institutes of Health
- Department of Defense
- Epilepsy Therapy Project
- Translational Research Program at Boston Children's Hospital
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Purpose: To examine the efficacy and safety profile of antiepileptic repetitive transcranial magnetic stimulation (rTMS) for refractory status epilepticus (RSE) in the intensive care unit (ICU) setting. In addition, hypothetical concerns about electrical interference of rTMS with ICU equipment have been previously raised. Methods: We describe two cases of RSE treated with rTMS in the ICU. Results: In one case, rTMS contributed to decreased seizure frequency; in the second case, rTMS transiently decreased seizure frequency. In both cases, rTMS was safe and did not interfere with the functioning of the ICU equipment. Conclusion: rTMS is a potential therapy for RSE when conventional therapies have failed. Future studies should investigate the efficacy of various rTMS stimulation parameters, safety issues, and bioengineering considerations in the ICU setting. (C) 2013 British Epilepsy Association. Published by Elsevier Ltd. All rights reserved.
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