Journal
SEIZURE-EUROPEAN JOURNAL OF EPILEPSY
Volume 19, Issue 7, Pages 446-449Publisher
W B SAUNDERS CO LTD
DOI: 10.1016/j.seizure.2010.06.002
Keywords
Antibodies; Epilepsy; GAD; Limbic encephalitis; Magnetic resonance imaging; Seizures
Categories
Ask authors/readers for more resources
Limbic encephalitis (LE) can be either paraneoplastic or a non-paraneoplastic autoimmune disorder. Magnetic resonance imaging (MRI) of the brain on T2-weighted fluid-attenuated inversion recovery (FLAIR) classically shows hyperintensities of the temporal structures, but multifocal involvement of extratemporal cortex has also been described in paraneoplastic LE. Here we describe a 27-year-old woman whose idiopathic autoimmune (glutamic acid decarboxylase-antibody positive) LE debuted with multiple daily mesio-temporal seizures, amnesia and multifocal extratemporal cortical MRI abnormalities. Mesio-temporal MRI signal increase was found after 20 days. This case report highlights that early diagnosis of non-paraneoplastic LE may be considered in patients with multiple daily mesio-temporal seizures and amnesia even in the absence of early typical MRI abnormalities. (C) 2010 British Epilepsy Association. Published by Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available