Journal
SCIENTIFIC REPORTS
Volume 5, Issue -, Pages -Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/srep12431
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- Shanghai Municipal Education Commission [14ZZ159]
- Shanghai Municipal Science and Technology Commission [12430501300]
- Program for Special Appointment (Eastern Scholar) at Shanghai Institutions of Higher Education
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Chan-Lam cross coupling allowed efficient synthesis of N,N'-disubstituted ortho-phenylene diamines bearing strong electron donating or withdrawing groups, such as nitro or methoxy groups, with moderate to high yields. These diamines can then be turned into N-heterocyclic carbene precursors after condensation with trimethyl orthoformate. The same strategy can also be utilized for the synthesis of N-monosubstituted aniline derivatives containing a functionalized ortho-aminomethyl group as intermediates for chiral 6-membered ring carbene precursors.
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