Journal
SCIENTIFIC REPORTS
Volume 5, Issue -, Pages -Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/srep14615
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Funding
- National Basic Research Program of China (973 Program) [2014CB541803, 2014CB541903]
- National Science Foundation of China [31200647, 81330072, 31370863, 31170825, 81270083, 31200646, 81271835, 81302532, 31300711]
- Shanghai Postdoctoral Sustentation Fund [12R21417100]
- China Postdoctoral Science Foundation [2012M520946]
- National Science and Technology Major Project Grants [2012ZX10002007-003, 2013ZX10003009-002, SMCST 11ZR1404900, 14JC1406100]
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The transcription factor FOXP3 is essential for the differentiation and function of regulatory T cells (Treg). It is established that the transcription factor GATA-3 is induced in Treg cells under inflammatory conditions. GATA-3 stabilizes FOXP3 levels to avoid the differentiation of Treg cells into inflammatory-like T cells. The IL-6 signal pathway influences the sensitivity of Treg cells towards instability. The mechanism of GATA-3 in regulating FOXP3 and its relation to the IL-6 pathway remains unclear. Here we report how miR-125a-5p plays an important role in regulating the conversion of Treg cells by IL-6. miR-125a-5p expression is low in Treg cells under steady state conditions and can be induced by GATA-3 to inhibit the expression of IL-6R and STAT3. This finding reveals a GATA3/miR-125a-5p/IL-6R and STAT3/FOXP3 regulatory pathway, which determines how Treg cells respond to inflammatory IL-6-rich conditions.
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