Journal
SCIENTIFIC REPORTS
Volume 5, Issue -, Pages -Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/srep08579
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Funding
- National Basic Research Program of China [2011CB933503]
- Major National Science and Technology Projects [2013ZX09301-303-003]
- National Natural Science Foundation of China [81473160, 81172955, 81302773]
- Fundamental Research Funds for the Central Universities [2242014R30013]
- Jiangsu Provincial Special Program of Medical Science [BL2013029]
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Iron oxide nanoparticles (IONPs) are chemically inert materials and have been mainly used for imaging applications and drug deliveries. However, the possibility whether they can be used as therapeutic drugs themselves has not yet been explored. We reported here that Fe2O3 nanoparticles (NPs) can protect hearts from ischemic damage at the animal, tissue and cell level. The cardioprotective activity of Fe2O3 NPs requires the integrity of nanoparticles and is not dependent upon their surface charges and molecules that were integrated into nanoparticles. Also, Fe2O3 NPs showed no significant toxicity towards normal cardiomyocytes, indicative of their potential to treat cardiovascular diseases.
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