Journal
SCIENTIFIC REPORTS
Volume 5, Issue -, Pages -Publisher
NATURE PORTFOLIO
DOI: 10.1038/srep13525
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Funding
- National Natural Science Foundation of China [81372409]
- Sun Yat-Sen University Clinical Research 5010 Program [2012011]
- Natural Science Foundation of Guangdong Province [S2013010012220]
- Science and Technology project of Guangzhou, City, China [132000507]
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This study is to identify significant dosimetric parameters for ear disorders in nasopharyngeal carcinoma (NPC) patients treated with intensity modulated therapy only. Ninety-seven patients with NPC were retrospectively reviewed. Organs at risk (OARs) in the auditory apparatus were contoured. Dose-volume histogram parameters were generated for the Eustachian tube (ET), tympanic cavity (TC), mastoid air cells, vestibular apparatus, cochlea and internal auditory canal (IAC). Ear disorders were rated 0 (none), 1 (mild) or 2 (severe) by a clinician blinded to radiation doses; Grade 2 ear disorders was the study end-point. Multivariate analysis revealed ET. D-30 (dose to 30% of ET volume) >52.75 Gy and M. D-0.5CC (dose to 0.5 ml of mastoid volume) >41.04 Gy (OR = 3.77, P=0.012 and OR = 1.27, P = 0.033, respectively) were associated with Grade 2 ear disorders. Our results demonstrated that post-irradiation ear disorders remain a common late toxicity in NPC after IMRT. ET.D-30 and M. D-0.5CC should be considered during IMRT treatment plan optimization, review and approval.
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