Journal
SCIENTIFIC REPORTS
Volume 5, Issue -, Pages -Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/srep14619
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Funding
- Hong Kong Baptist University [FRG2/14-15/004, RC-IRMS/14-15/06]
- Health and Medical Research Fund [HMRF/13121482, HMRF/14130522]
- Research Grants Council [HKBU/201811, HKBU/204612, HKBU/201913]
- French National Research Agency/Research Grants Council Joint Research Scheme [A-HKBU201/12]
- State Key Laboratory of Environmental and Biological Analysis Research Grant [SKLP-14-15-P001]
- National Natural Science Foundation of China [21575121]
- Guangdong Province Natural Science Foundation [2015A030313816]
- State Key Laboratory of Synthetic Chemistry
- Science and Technology Development Fund, Macao SAR [103/2012/A3, 098/2014/A2]
- University of Macau [MYRG091(Y3-L2)-ICMS12-LCH, MYRG2015-00137-ICMS-QRCM, MRG023/LCH/2013/ICMS]
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We report herein the application of kinetically inert luminescent iridium(III) complexes as dual inhibitors and probes of beta-amyloid fibrillogenesis. These iridium(III) complexes inhibited A beta(1-40) peptide aggregation in vitro, and protected against A beta-induced cytotoxicity in neuronal cells. Furthermore, the complexes differentiated between the aggregated and unaggregated forms of A beta(1-40) peptide on the basis of their emission response.
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