Journal
SCIENTIA IRANICA
Volume 18, Issue 6, Pages 1356-1364Publisher
SHARIF UNIV TECHNOLOGY
DOI: 10.1016/j.scient.2011.11.005
Keywords
Nano-ordered borosilicate (B-MCM-41); Multi-component reactions; Strecker reaction; alpha-amino nitriles; Carbonyl compounds; TMSCN
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Funding
- Research Council of Iran University of Science and Technology (IUST), Iran [160/5354]
- Iran Nanotechnology Initiative Council (INIC)
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The three-component Strecker reaction of a wide range of aldehydes or ketones and different amines with trimethylsilyl cyanide (TMSCN) was efficiently catalyzed by the nano-ordered mesoporous borosilicate (B-MCM-41) at room temperature to afford the corresponding alpha-amino nitriles in high to quantitative yields in short reaction time. B-MCM-41 showed higher catalytic activity than Fe(III)-modified MCM-41 (Fe-MCM-41). Furthermore, the use of EtOH increased the rate of reaction remarkably compared to CH2Cl2 or CH3CN. The B-MCM-41 catalyst can be recovered at least 4 times without significant loss of its catalytic activity. (C) 2012 Sharif University of Technology. Production and hosting by Elsevier B.V. All rights reserved.
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