Journal
SCIENTIFIC REPORTS
Volume 5, Issue -, Pages -Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/srep14302
Keywords
-
Categories
Funding
- National Basic Research Program of China [2014CB744402]
- National Natural Science Foundation of China [30970117]
- National Science and Technology Major Project of China [2013ZX10004-601]
- Special Research Foundation for Traditional Chinese Medicine [200907001]
- Program for Changjiang Scholars and Innovative Research Team in University [IRT13007]
- Fundamental Research Funds for the Central Universities [3332013118]
Ask authors/readers for more resources
Viruses evolve multiple ways to interfere with NF-kappa B signaling, a key regulator of innate and adaptive immunity. Enterovirus 71 (EV71) is one of primary pathogens that cause hand-foot-mouth disease. Here, we identify RelA(p65) as a novel binding partner for EV71 2C protein from yeast twohybrid screen. By interaction with IPT domain of p65, 2C reduces the formation of heterodimer p65/p50, the predominant form of NF-kappa B. We also show that picornavirus 2C family proteins inhibit NF-kappa B activation and associate with p65 and IKK beta. Our findings provide a novel mechanism how EV71 antagonizes innate immunity.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available