Journal
SCIENCE TRANSLATIONAL MEDICINE
Volume 6, Issue 219, Pages -Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/scitranslmed.3007828
Keywords
-
Categories
Funding
- Damon Runyon Clinical Investigator Award [R01 AR056720, R01 AR063962, R03 MH095529]
- SPORE in Skin Cancer [P50 CA9368305, R01 A1025082, R01 AI097128]
- Swiss National Science Foundation
- Fondation Rene Touraine
- Leukemia & Lymphoma Society
- German Research Foundation
Ask authors/readers for more resources
T helper type 9 (T(H)9) cells can mediate tumor immunity and participate in autoimmune and allergic inflammation in mice, but little is known about the TH9 cells that develop in vivo in humans. We isolated T cells from human blood and tissues and found that most memory T-H(9) cells were skin-tropic or skin-resident. Human T-H(9) cells coexpressed tumor necrosis factor-a and granzyme B and lacked coproduction of TH1/TH2/TH17 cytokines, and many were specific for Candida albicans. Interleukin-9 (IL-9) production was transient and preceded the up-regulation of other inflammatory cytokines. Blocking studies demonstrated that IL-9 was required for maximal production of interferon-g, IL-9, IL-13, and IL-17 by skin-tropic T cells. IL-9-producing T cells were increased in the skin lesions of psoriasis, suggesting that these cells may contribute to human inflammatory skin disease. Our results indicate that human TH9 cells are a discrete T cell subset, many are tropic for the skin, and although they may function normally to protect against extracellular pathogens, aberrant activation of these cells may contribute to inflammatory diseases of the skin.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available