Journal
SCIENTIFIC REPORTS
Volume 5, Issue -, Pages -Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/srep17702
Keywords
-
Categories
Funding
- Specialized Research Fund for the Doctoral Program of Higher Education [20133227110008]
- Health Department Foundation of Jiangsu Province [Z201312]
- National Natural Science Foundation of China [31470881, 31270947]
- Natural Science Foundation of Jiangsu [BK20150533]
- Specialized Project for Clinical Medicine of Jiangsu Province [BL2014065]
- Science and Technology Support Program (Social Development) of Zhenjiang [SH2015045, SH2013040]
- Jiangsu Province 333 Project [BRA2015197]
- Summit of the Six Top Talents Program of Jiangsu Province [2015-WSN-116]
- Jiangsu University Initial Founding for Advanced Talents [15JDG070, 11JDG093]
- Jiangsu Key Laboratory of Laboratory Medicine Foundation [JSKLM-2014-013]
- Priority Academic Program Development of Jiangsu Higher Education Institutions
Ask authors/readers for more resources
The long noncoding (lnc) RNA-Ifng-AS1 plays an essential role in the transcription of the gene encoding IFN-gamma by Th1 cells, and its human ortholog, IFNG-AS1, is expressed in human Th1 cells. However, IFNG-AS1 contributing to Th1 cells' response in Hashimoto's thyroiditis (HT) patients has not been reported. Twenty-eight HT patients and 20 healthy controls were enrolled in the study. The proportion of circulating Th1 cells and the level of T-bet, IFNG mRNA were increased in HT patients, the expression of IFNG-AS1 was upregulated and positively correlated with the proportion of circulating Th1 cells or T-bet, and IFNG expression, or serum level of anti-thyroglobulin antibody/thyroperoxidase antibody in HT patients. IFNG-AS1 regulated the expression of IFNG at both transcriptional and translational level in human CD4(+) T cells. Furthermore, strong positive correlations between the increased transcript level of IFNG-AS1 and the increased transcript level of T-bet or IFNG were revealed in thyroid tissues from HT patients. Our results indicate that enhanced expression of lncRNA-IFNG-AS1 contributes to Th1 cell response in HT patients and may be involved in the pathogenesis of HT.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available