Journal
SCIENCE TRANSLATIONAL MEDICINE
Volume 5, Issue 179, Pages -Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/scitranslmed.3005568
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Funding
- Medical Research Program Grant from the W.M. Keck Foundation
- David and Lucile Packard Foundation
- JDRF
- CIRM Disease Team
- NSF SynBERC
- NIH [OD007290, AI101018, AI101722, R01 AI46643, P50 GM081879]
- Howard Hughes Medical Institute
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Two decades ago, the pharmaceutical industry-long dominated by small-molecule drugs-was revolutionized by the the advent of biologics. Today, biomedicine sits on the cusp of a new revolution: the use of microbial and human cells as versatile therapeutic engines. Here, we discuss the promise of this third pillar of therapeutics in the context of current scientific, regulatory, economic, and perceptual challenges. History suggests that the advent of cellular medicines will require the development of a foundational cellular engineering science that provides a systematic framework for safely and predictably altering and regulating cellular behaviors.
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