4.8 Article

Piecing Together the Puzzle of Severe Malaria

Journal

SCIENCE TRANSLATIONAL MEDICINE
Volume 5, Issue 211, Pages -

Publisher

AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/scitranslmed.3007432

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Funding

  1. Medical Research Council [G0701427] Funding Source: Medline
  2. MRC [G0701427] Funding Source: UKRI
  3. Medical Research Council [G0701427] Funding Source: researchfish

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Severe malaria manifests as several overlapping syndromes with high mortality. Interaction of parasites with endothelial protein C receptors and high parasite biomass have recently been identifed as key determinants of severe disease. However, gaps in our understanding of severe malaria might hinder translation of these fndings into new therapies.

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