Journal
SCIENCE TRANSLATIONAL MEDICINE
Volume 4, Issue 160, Pages -Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/scitranslmed.3003688
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Funding
- U.S. National Institutes of Health (NIH) [HL092836, DE021468, EB012597, HL099073, EB024618, EB012726]
- National Science Foundation [DMR0847287]
- NIH/NCI Center for Oncophysics [CTO PSOC U54-CA-143837]
- DTRA
- Office of Naval Research Young Investigator award
- Kyung Hee University [KHU-20120477]
- Division Of Materials Research
- Direct For Mathematical & Physical Scien [0847287] Funding Source: National Science Foundation
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Only a few engineered tissues-skin, cartilage, bladder-have achieved clinical success, and biomaterials designed to replace more complex organs are still far from commercial availability. This gap exists in part because biomaterials lack a vascular network to transfer the oxygen and nutrients necessary for survival and integration after transplantation. Thus, generation of a functional vasculature is essential to the clinical success of engineered tissue constructs and remains a key challenge for regenerative medicine. In this Perspective, we discuss recent advances in vascularization of biomaterials through the use of biochemical modification, exogenous cells, or microengineering technology.
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