Journal
SCIENCE TRANSLATIONAL MEDICINE
Volume 3, Issue 73, Pages -Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/scitranslmed.3001713
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Funding
- American Cancer Society [PF-08-196-01-MGO]
- University of California
- San Francisco G.W. Hooper Research Foundation
- NIH [R01 CA136717, U54-A1065359]
- National Science Foundation [CMMI-0846323, CMMI-0856492]
- Center for Scalable and Integrated NanoManufacturing [DMI-0327077]
- National Center for Learning and Teaching
- V Foundation for Cancer Research
- Wallace H. Coulter Foundation
- Northwestern University
- Weinberg College of Arts and Sciences
- NEDO, Japan
- Directorate For Engineering [0751621] Funding Source: National Science Foundation
- Directorate For Engineering
- Div Of Civil, Mechanical, & Manufact Inn [0856492] Funding Source: National Science Foundation
- Div Of Civil, Mechanical, & Manufact Inn [0751621] Funding Source: National Science Foundation
- Div Of Civil, Mechanical, & Manufact Inn
- Directorate For Engineering [0846323] Funding Source: National Science Foundation
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Enhancing chemotherapeutic efficiency through improved drug delivery would facilitate treatment of chemoresistant cancers, such as recurrent mammary tumors and liver cancer. One way to improve drug delivery is through the use of nanodiamond (ND) therapies, which are both scalable and biocompatible. Here, we examined the efficacy of an ND-conjugated chemotherapeutic in mouse models of liver and mammary cancer. A complex (NDX) of ND and doxorubicin (Dox) overcame drug efflux and significantly increased apoptosis and tumor growth inhibition beyond conventional Dox treatment in both murine liver tumor and mammary carcinoma models. Unmodified Dox treatment represents the clinical standard for most cancer treatment regimens, and NDX had significantly decreased toxicity in vivo compared to standard Dox treatment. Thus, ND-conjugated chemotherapy represents a promising, biocompatible strategy for overcoming chemoresistance and enhancing chemotherapy efficacy and safety.
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