Dissecting the Immune Cell Mayhem That Drives Lupus Pathogenesis

The autoimmune disease systemic lupus erythematosus (SLE) results from an inability of the immune system to discriminate between certain self-antigens and foreign ones. The most common treatment of SLE involves the use of immunosuppressive drugs to reduce inflammation, but these therapies have serious side effects. Three recent papers in Science Translational Medicine redirect focus on neutrophils, platelets, and interferon-a in the pathogenesis of SLE and reinforce the notion that researchers should seek to discover and devise combination therapies that target these processes.