Journal
SCIENCE TRANSLATIONAL MEDICINE
Volume 2, Issue 27, Pages -Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/scitranslmed.3000330
Keywords
-
Categories
Funding
- MRC [G9439390, G0600986, G0001237] Funding Source: UKRI
- Medical Research Council [G0001237, G0600986, G9439390] Funding Source: researchfish
- National Institute for Health Research [NF-SI-0508-10327] Funding Source: researchfish
- Medical Research Council [G0600986, G9439390, G0001237] Funding Source: Medline
- Wellcome Trust Funding Source: Medline
Ask authors/readers for more resources
Worldwide, traumatic brain injury (TBI) is a major cause of mortality and morbidity with a substantial predicted increase in incidence. Despite an obvious need, there are no pharmacological treatment options for TBI because translation of neuroprotection from preclinical studies to clinical practice has so far failed. Here, we identify potential causes for this failure. We suggest that those monitoring and investigation tools that are commonly used in patients with TBI may provide an experimental medicine route to facilitate a more rational approach to translational research. This suggestion is underpinned by existing research data on disease biology, drug delivery, and treatment response obtained with these methods.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available