Journal
SCIENCE TRANSLATIONAL MEDICINE
Volume 2, Issue 18, Pages -Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/scitranslmed.3000447
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Categories
Funding
- NIH [MH083552, AI077304, AI69432, AI38858, AI43638, AI074621, AI43752, AI29164, AI47745, MH62512, AI047745, AI57167]
- National Science Foundation [NSF-0714991]
- University of California, San Diego, Center for AIDS Research [AI36214]
- Centers for Disease Control and Prevention [200-2002-00656]
- San Diego Veterans Affairs Healthcare System
- Pfizer
- Division Of Mathematical Sciences
- Direct For Mathematical & Physical Scien [0714991] Funding Source: National Science Foundation
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Although it is known that most HIV-1 infections worldwide result from exposure to virus in semen, it has not yet been established whether transmitted strains originate as RNA virions in seminal plasma or as integrated proviral DNA in infected seminal leukocytes. We present phylogenetic evidence that among six transmitting pairs of men who have sex with men, blood plasma virus in the recipient is consistently more closely related to the seminal plasma virus in the source. All sequences were subtype B, and the env C2V3 of transmitted variants tended to have higher mean isoelectric points, contain potential N-linked glycosylation sites, and favor CCR5 co-receptor usage. A statistically robust phylogenetically corrected analysis did not detect genetic signatures reliably associated with transmission, but further investigation of larger samples of transmitting pairs holds promise for determining which structural and genetic features of viral genomes are associated with
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