Journal
SCIENCE TRANSLATIONAL MEDICINE
Volume 2, Issue 47, Pages -Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/scitranslmed.3001442
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Funding
- NIH [CA106512, CA015704, DK056465]
- Fred Hutchinson Cancer Research Center
- Thomsen Family Fellowship
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Diversity in T lymphocyte antigen receptors is generated by somatic rearrangement of T cell receptor (TCR) genes and is concentrated within the third complementarity-determining region 3 (CDR3) of each chain of the TCR heterodimer. We sequenced the CDR3 regions from millions of rearranged TCR beta chain genes in nave and memory CD8(+) T cells of seven adults. The CDR3 sequence repertoire realized in each individual is strongly biased toward specific V-beta-J(beta) pair utilization, dominated by sequences containing few inserted nucleotides, and drawn from a defined subset comprising less than 0.1% of the estimated 5 x 10(11) possible sequences. Surprisingly, the overlap in the naive CD8(+) CDR3 sequence repertoires of any two of the individuals is similar to 7000-fold larger than predicted and appears to be independent of the degree of human leukocyte antigen matching.
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