Journal
SCIENCE SIGNALING
Volume 7, Issue 350, Pages -Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/scisignal.2005671
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Funding
- Deutsche Forschungsgemeinschaft [CECAD, FOR885, SFB635, KFO 286, 2014376]
- European Research Council [616499]
- European Research Council (ERC) [616499] Funding Source: European Research Council (ERC)
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The endoplasmic reticulum (ER) is a cellular compartment that has a key function in protein translation and folding. Maintaining its integrity is of fundamental importance for organism's physiology and viability. The dynamic regulation of intraluminal ER Ca2+ concentration directly influences the activity of ER-resident chaperones and stress response pathways that balance protein load and folding capacity. We review the emerging evidence that microRNAs play important roles in adjusting these processes to frequently changing intracellular and environmental conditions to modify ER Ca2+ handling and storage and maintain ER homeostasis.
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