Journal
SCIENCE SIGNALING
Volume 2, Issue 60, Pages -Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/scisignal.2000016
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Funding
- NIDCD NIH HHS [F32 DC008932, R01 DC005782-06A1, R01 DC005782-03, F31 DC008480-01, R01 DC005782-04, F32 DC008932-01A2, R01 DC005782-02, R01 DC005782-05, R01 DC005782, R01 DC005782-01, F32 DC008932-02, F31 DC008480-02] Funding Source: Medline
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Deciphering olfactory encoding requires a thorough description of the ligands that activate each odorant receptor (OR). In mammalian systems, however, ligands are known for fewer than 50 of more than 1400 human and mouse ORs, greatly limiting our understanding of olfactory coding. We performed high-throughput screening of 93 odorants against 464 ORs expressed in heterologous cells and identified agonists for 52 mouse and 10 human ORs. We used the resulting interaction profiles to develop a predictive model relating physicochemical odorant properties, OR sequences, and their interactions. Our results provide a basis for translating odorants into receptor neuron responses and for unraveling mammalian odor coding.
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