Journal
SCIENCE SIGNALING
Volume 2, Issue 67, Pages -Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/scisignal.267pe27
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Funding
- Medical Research Council [MC_U127015387] Funding Source: researchfish
- MRC [MC_U127015387] Funding Source: UKRI
- Medical Research Council [MC_U127015387] Funding Source: Medline
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The mammalian target of rapamycin complex 2 (mTORC2) plays critical roles in regulating cell growth and proliferation. mTORC2 promotes the activation of the serum glucocorticoid-induced protein kinase (SGK). This mTOR complex also promotes the constitutive phosphorylation of proline-directed serine or threonine sites in the turn motif of Akt and protein kinase C isoforms. mTORC2 may control phosphorylation of the turn motif by promoting the activity of a kinase that targets the Ser/Thr-Pro sequence or by inhibiting the activity of a phosphatase.
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