Journal
SCIENCE SIGNALING
Volume 2, Issue 98, Pages -Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/scisignal.298pe77
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Funding
- NCI NIH HHS [T32 CA009140] Funding Source: Medline
- NCRR NIH HHS [S10 RR024525] Funding Source: Medline
- NIAID NIH HHS [T32 AI060516, F32 AI072943, R01 AI074878, R01 AI074878-02, R01 AI095466, T32 AI007532, T32 AI055438, R01 AI061570, R01 AI061570-06] Funding Source: Medline
- NIGMS NIH HHS [F31 GM082187] Funding Source: Medline
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The first reports of diplomatic relations between human communities date back to the 14th century B. C. E. and the age of the Egyptian pharaohs. However, the evolution of analogous relations between mammals and mutualistic microbial communities is as old as multicellular organisms themselves. A fundamental issue surrounding the biology of these mutualistic relationships is how the immune system recognizes beneficial microbes and tolerates their colonization of barrier surfaces while simultaneously preventing their outgrowth and potentially lethal dissemination throughout the host. New evidence provides insight into the molecular mechanisms that orchestrate diplomacy between the mammalian immune system and bacterial communities in the gut.
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