Journal
SCIENCE OF THE TOTAL ENVIRONMENT
Volume 438, Issue -, Pages 225-232Publisher
ELSEVIER
DOI: 10.1016/j.scitotenv.2012.08.066
Keywords
Nanoparticles; Dissolution; Nanotoxicology; Toxicology; Physicochemical properties; Solubility
Categories
Funding
- QNano Project
- European Community Research Infrastructures under the FP7 Capacities Programme FP7 [262163]
- US-EPA
- UK-NERC-ESPRC Research Program Grant [RD-834557501-0]
- NERC [NE/H013199/1] Funding Source: UKRI
- Natural Environment Research Council [NE/H013199/1] Funding Source: researchfish
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Dissolution of nanoparticles (NPs) is an important property that alters their abundance and is often a critical step in determining safety of nanoparticles. The dissolution status of the NPs in exposure media (i.e. whether they remain in particulate form or dissolve - and to what extent), strongly affects the uptake pathway, toxicity mechanisms and the environmental compartment in which NPs will have the highest potential impact. A review of available dissolution data on NPs demonstrates there is a range of potential outcomes depending on the NPs and the exposure media. For example two nominally identical nanoparticles, in terms of size and composition, could have totally different dissolution behaviours, subject to different surface modifications. Therefore, it is imperative that toxicological studies are conducted in conjunction with dissolution of NPs to establish the true biological effect of NPs and hence, assist in their regulation. (c) 2012 Elsevier B.V. All rights reserved.
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