Modelling air pollution for epidemiologic research - Part I: A novel approach combining land use regression and air dispersion

A common limitation of epidemiological studies on health effects of air pollution is the quality of exposure data available for study participants Exposure data derived from urban monitoring networks is usually not adequately representative of the spatial variation of pollutants, while personal monitoring campaigns are often not feasible, due to time and cost restrictions Therefore, many studies now rely on empirical modelling techniques, such as land use regression (LUR), to estimate pollution exposure However, LUR still requires a quantity of specifically measured data to develop a model, which is usually derived from a dedicated monitoring campaign A dedicated air dispersion modelling exercise is also possible but is similarly resource and data intensive This study adopted a novel approach to LUR, which utilised existing data from an air dispersion model rather than monitored data There are several advantages to such an approach such as a larger number of sites to develop the LUR model compared to monitored data Furthermore, through this approach the LUR model can be adapted to predict temporal variation as well as spatial variation The aim of this study was to develop two LUR models for an epidemiologic study based in Greater Manchester by using modelled NO2 and PM10 concentrations as dependent variables, and traffic intensity, emissions, land use and physical geography as potential predictor variables The LUR models were validated through a set aside validation dataset and data from monitoring stations The final models for PM10 and NO2 comprised nine and eight predictor variables respectively and had determination coefficients (R-2) of 0 71 (PM10 Adj R-2 = 0 70. F = 54 89, p<0 001, NO2 Adj R-2 = 0 70, F = 62 04, p<0 001) Validation of the models using the validation data and measured data showed that the R2 decreases compared to the final models, except for NO2 validation in the measured data (validation data PM10 R-2 = 0 33, NO2 R-2 = 0 62, measured data PM10 R-2 = 0 56, NO2 R-2 = 0 86) The validation further showed low mean prediction errors and root mean squared errors for both models (C) 2010 Elsevier B V All rights reserved