Journal
SCIENCE CHINA-TECHNOLOGICAL SCIENCES
Volume 57, Issue 10, Pages 2020-2027Publisher
SCIENCE PRESS
DOI: 10.1007/s11431-014-5653-7
Keywords
Parkinson's disease; beta oscillations; stability; delay
Funding
- National Natural Science Foundation of China [11325208, 11172017]
- Research Fund for the Doctoral Program of Higher Education [20121102110014]
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The persistence of beta oscillations generated in the basal ganglia is typical pathological characteristic of Parkin-son's disease. In this paper, we construct a new network model, which is mainly composed of the subthalamic nu-cleus and the globus pallidus. Based on theory analysis, we obtained the beta shock conditions in the proposed model. It is shown that numerical simulations are in good agreement with analytical results. At last, the effects of cortex and striatum inputs on the generation of oscillations are also discussed. We hope that the obtained results may find applications to treatment of Parkinson's disease and study of neural oscillations produced in other parts of the brain neural network.
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