4.6 Article

Base-mediated direct fluoroalkenylation of 2-phenyl-1,3,4-oxadiazole, benzothiazole and benzoxazole with gem-difluoroalkenes

Journal

RSC ADVANCES
Volume 5, Issue 11, Pages 7905-7908

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c4ra13761b

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Funding

  1. National Natural Science Foundation of China [21472043, 21272070]
  2. National Science AMP
  3. Technology Pillar Program of China [2011BAE06B01-15]

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Direct alpha-fluorovinylation of 2-phenyl-1,3,4-oxadiazole, benzothiazole and benzoxazole with gem-difluoroalkenes via nucleophilic vinylic substitution reaction (SNV) under the assistance of KHMDS or NaH at room temperature is described.

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