Journal
SCIENCE CHINA-LIFE SCIENCES
Volume 57, Issue 3, Pages 315-326Publisher
SCIENCE PRESS
DOI: 10.1007/s11427-013-4577-y
Keywords
Epstein-Barr virus (EBV); microRNA (miRNA); nasopharyngeal carcinoma (NPC); gene regulate network
Categories
Funding
- National Natural Science Foundation of China [81172189, 81171930, 81272298, 81272254, 91229122, 81301757, 81372907]
- Natural Science Foundation of Hunan Province [14JJ1010]
- Fundamental Research Funds for the Central Universities [2011JQ020]
- Postdoctoral Science Foundation of Central South University
Ask authors/readers for more resources
Epstein-Barr virus (EBV) is associated with nasopharyngeal carcinoma (NPC) tumorigenesis. However, the mechanism(s) connecting EBV infection and NPC remain unclear. Recently, a new class of EBV microRNAs (miRNAs) has been described. To determine how EBV miRNAs control the expression of host genes, and to understand their potential role in NPC tumorigenesis, we profiled the expression of 44 mature EBV miRNAs and potential host genes in NPC and non-tumor nasopharyngeal epithelial tissues. We found that 40 EBV miRNAs from the BART transcript were highly expressed in NPC. Analysis of potential BART miRNA target genes revealed that 3140 genes and several important pathways might be involved in the carcinogenesis of NPC. A total of 105 genes with potential EBV miRNA binding sites were significantly downregulated, suggesting that EBV miRNAs may regulate these genes and contribute to NPC carcinogenesis. An EBV miRNA and host gene regulation network was generated to provide useful clues for validating of EBV miRNA functions in NPC tumorigenesis.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available