Journal
SCIENCE CHINA-LIFE SCIENCES
Volume 55, Issue 1, Pages 27-34Publisher
SCIENCE PRESS
DOI: 10.1007/s11427-012-4272-4
Keywords
GPCR signaling; visual transduction; rhodopsin; TRP channels; Drosophila
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Funding
- National Natural Science Foundation of China [30970663, 31070683]
- New-Century Training Program Foundation for the Talents by the State Education Commission
- Youth Foundation of Southeast University
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The Drosophila visual transduction is the fastest known G protein-coupled signaling cascade and has been served as a model for understanding the molecular mechanisms of other G protein-coupled signaling cascades. Numbers of components in visual transduction machinery have been identified. Based on the functional characterization of these genes, a model for Drosophila phototransduction has been outlined, including rhodopsin activation, phosphoinoside signaling, and the opening of TRP and TRPL channels. Recently, the characterization of mutants, showing slow termination, revealed the physiological significance and the mechanism of rapid termination of light response.
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