Journal
SCIENCE CHINA-LIFE SCIENCES
Volume 53, Issue 9, Pages 1085-1091Publisher
SCIENCE PRESS
DOI: 10.1007/s11427-010-4057-6
Keywords
substrate orientation; osteoblasts; cell shape; cell cycle; cytoskeleton
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Funding
- Chinese Academy of Sciences [KJCX2-YW-L08]
- National Natural Science Foundation of China [30730032, 30730093]
- National Key Basic Research Foundation of China [2006CB910303]
- National High Technology Research and Development Program of China [2007AA02Z306]
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Absence of gravity or microgravity influences the cellular functions of bone forming osteoblasts. The underlying mechanism, however, of cellular sensing and responding to the gravity vector is poorly understood. This work quantified the impact of vector-directional gravity on the biological responses of Ros 17/2.8 cells grown on upward-, downward- or edge-on-oriented substrates. Cell morphology and nuclear translocation, cell proliferation and the cell cycle, and cytoskeletal reorganization were found to vary significantly in the three orientations. All of the responses were duration-dependent. These results provide a new insight into understanding how osteoblasts respond to static vector-directional gravity.
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