Journal
SCIENCE CHINA-CHEMISTRY
Volume 57, Issue 12, Pages 1605-1614Publisher
SCIENCE PRESS
DOI: 10.1007/s11426-014-5235-3
Keywords
DNA G-quadruplexes; oncogene promoters; human telomeres; G-quadruplex-targeted small molecules; anticancer drug target
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Funding
- NCI NIH HHS [R01 CA122952, R01 CA153821, R01 CA177585] Funding Source: Medline
- NIGMS NIH HHS [R01 GM083117] Funding Source: Medline
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G-quadruplex secondary structures are four-stranded globular nucleic acid structures form in the specific DNA and RNA G-rich sequences with biological significance such as human telomeres, oncogene-promoter regions, replication initiation sites, and 5' and 3'-untranslated (UTR) regions. The non-canonical G-quadruplex secondary structures can readily form under physiologically relevant ionic conditions and are considered to be new molecular target for cancer therapeutics. This review discusses the essential progress in our lab related to the structures and functions of biologically relevant DNA G-quadruplexes in human gene promoters and telomeres, and the opportunities presented for the development of G-quadruplex-targeted small-molecule drugs.
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