Journal
SCIENCE CHINA-CHEMISTRY
Volume 57, Issue 4, Pages 461-475Publisher
SCIENCE PRESS
DOI: 10.1007/s11426-014-5076-0
Keywords
biodegradable polymer; micelle; amphiphilicity; drug-delivery system; cancer
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Funding
- National Basic Research Program of China [2011CB606206]
- National Natural Science Foundation of China [21372170, 51133004, 81361140343]
- Recruitment Program of Global Young Experts of China
- Setup Foundation of Sichuan University [YJ201317]
- Excellent Young Teachers Program of Sichuan University [2082604164235]
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The use of nanotechnology in drug-delivery systems (DDS) is attractive for advanced diagnosis and treatment of cancer diseases. Biodegradable polymeric nanoparticles, for example, have promising applications as advanced drug carriers in cancer treatment. In this review, we discuss the development of drug-delivery systems based on an amphiphilic principle mainly conducted by our group for anti-cancer drug delivery. We first briefly address the synthetic chemistry for amphiphilic biodegradable polymers. In the second part, we summarize progress in the application of self-assembled polymer micelles using amphiphilic biodegradable copolymers as anti-tumor drug carriers.
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