Journal
SCIENCE CHINA-CHEMISTRY
Volume 56, Issue 7, Pages 939-944Publisher
SCIENCE PRESS
DOI: 10.1007/s11426-013-4874-0
Keywords
enzyme catalysis; aldol reaction; proteinase; promiscuity; asymmetric synthesis
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The direct asymmetric aldol reaction of aromatic aldehydes with cyclic or acyclic ketones was catalyzed by proteinase from Aspergillus melleus (AMP) in acetonitrile in the presence of water. A wide range of substrates could be transformed into the corresponding aldol products in yields up to 89%, enantioselectivities up to 91% ee and diastereoselectivities up to > 99:1 (anti/syn). This work provided an example of enzyme catalytic promiscuity that widens the applicability of this biocatalyst in organic synthesis without the need for additional cofactors or special equipment.
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