4.7 Article

Synthesis of naphthalene derivatives through inexpensive BF3•Et2O-catalyzed annulation reaction of arylacetaldehydes with arylalkynes

Journal

SCIENCE CHINA-CHEMISTRY
Volume 56, Issue 7, Pages 945-951

Publisher

SCIENCE PRESS
DOI: 10.1007/s11426-013-4843-7

Keywords

naphthalene derivatives; BF3 center dot Et2O; arylacetaldehydes; arylalkynes; annulation reaction

Funding

  1. Sichuan Provincial Department of Education [11ZA108]
  2. National Natural Science Foundation of China [21202109, 21072140]
  3. Sichuan Normal University for Sharing the Large Precision Equipments [DJ2012-07, DJ2011-16]
  4. Sichuan Normal University

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An inexpensive BF3 center dot Et2O-catalyzed annulation reaction of arylacetaldehydes with arylalkynes has been developed. Various substituted phenylacetaldehydes and phenylacetylenes can undergo this reaction, producing corresponding alpha-aryl substituted naphthalene derivatives. Use of inexpensive and readily available BF3 center dot Et2O catalyst constitutes the most attractive advantage of this transformation.

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