Journal
SCIENCE CHINA-CHEMISTRY
Volume 53, Issue 11, Pages 2265-2271Publisher
SCIENCE PRESS
DOI: 10.1007/s11426-010-4114-9
Keywords
nano-graphene oxide; photodynamic therapy; photosensitizer; drug delivery; biomedical application
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Funding
- Shanghai Nanotechnology [0952nm04800]
- Shanghai Postdoctoral Fund [10R21415700]
- Shanghai Natural Science Foundation [10ZR1432100]
- Shanghai Municipal Education Commission [20091619]
- Program for Young Excellent Talents in Tongji University
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A novel methoxy-poly(ethylene glycol) modified nano-graphene oxide (NGO-mPEG) was designed and synthesized as a photosensitizer (PS) carrier for photodynamic therapy of cancer. NGO with a size below 200 nm was prepared using a modified Hummers' method. NGO was observed by AFM to exhibit a structure with single-layer graphene oxide sheets down to a few nanometers in height. Hydrophilic mPEG conjugation of NGO (NGO-mPEG) was found to enhance solubility in cell culture media. No apparent cytotoxicity of the NGO-mPEG was observed towards MCF-7 carcinoma cell line. Zinc phthalocyanine (ZnPc), a photosensitizer for photodynamic therapy, was loaded in the NGO-PEG through pi-pi stacking and hydrophobic interactions, with the drug loading efficiency up to 14 wt%. Hydrophobic ZnPc was internalized in MCF-7 cells, exhibiting a pronounced phototoxicity in the cells under Xe light irradiation. The results indicate a great potential of NGO-mPEG for photodynamic therapy of cancer.
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